This work was supported by Ministerio de Economía y Competitividad, co-funded by FEDER (MINECO-17-BFU2016–79139-R), and sponsorshipfrom Ministerio de Educación, Cultura y Deporte (AP2012–4924; to P.G.-M.). The authors thank Marisa Lopez-Cruzan (UT Health Science Center,Texas, EEUU) for checking English grammar.