Synthesis of mesoporous silica nanoparticles and nanorods: Application to doxorubicin delivery
- Resource Type
- Authors
- Jean-Olivier Durand; Mokhtar Férid; Magali Gary-Bobo; Saher Rahmani; Clarence Charnay; Laure Lichon; Marcel Garcia
- Source
- Solid State Sciences. 68:25-31
- Subject
- animal structures
Chromatography
Ethanol
Nanoparticle
02 engineering and technology
General Chemistry
Mesoporous silica
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
01 natural sciences
0104 chemical sciences
chemistry.chemical_compound
chemistry
Cancer cell
Drug delivery
medicine
Particle
General Materials Science
Doxorubicin
Nanorod
sense organs
0210 nano-technology
medicine.drug
Nuclear chemistry
- Language
- ISSN
- 1293-2558
The synthesis and application of mesoporous silica nanoparticles (MSN) and mesoporous silica nanorods (MSNR) for drug delivery were described. MSN or MSNR were obtained by adjusting the amount of added cosolvent to the sol-gel solution. Therefore, the addition of ethanol (EtOH) has contributed to the control of the particle shape and to the structure of the mesoporosity. MSN and MSNR particles were then loaded with doxorubicin and incubated with MCF-7 breast cancer cells. MSN and MSNR particles were efficient in killing cancer cells but their behavior in drug delivery was altered on account of the difference in their morphology. MSN showed a burst release of doxorubicin in cells whereas MSNR showed a sustained delivery of the anti-cancer drug.