Table S1. Genomic characteristics of WM with TP53 aberration; Figure S1: Delineation of 17p minimal deleted region detected by SNP array in Waldenstrom's macroglobulinemia; Figure S2. (1) Nutlin-3a effects on WM cells. Impact of nutlin-3a (10 μM, 16h) on p53 targets (p53, p21, puma, MDM2) in different cell lines; Figure S3. (1) Ibrutinib did not increase expression of the p53 target. Impact of ibrutinib and nutlin 3a as reference drug on p53 targets (p53, p21, puma, MDM2) in different cell lines; Figure S4. Patterns of response to CP31398 and PrimaMet in WM. CP31398 and PrimaMet induces cell death independent of TP53 mutational status.