Biological Evolution of Titanium(IV) Complex [{(NNO)2Ti}3O3] Bearing Bidentate Heteroditopic Schiff Base Ligand: Synthesis, Structure and Biological Studies
- Resource Type
- Authors
- S. Rex Jeya Rajkumar; Venkatesan Srinivasadesikan; Shiva Krishna Loke; Ravi K. Kottalanka; Eswar Pagadala; Balajee Ramchandran
- Source
- Asian Journal of Chemistry. 32:441-450
- Subject
- Bearing (mechanical)
Biological studies
Schiff base
Denticity
010405 organic chemistry
Ligand
chemistry.chemical_element
02 engineering and technology
General Chemistry
Biological evolution
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
law.invention
chemistry.chemical_compound
chemistry
law
Polymer chemistry
0210 nano-technology
Titanium
- Language
- ISSN
- 0975-427X
0970-7077
Titanium(IV)-complex of chemical composition [{(NNO)2Ti}3O3] (2) bearing bidentate heteroditopic Schiff base [(C5H4OH)-N=CH-C4H3-NH] (L1) ligand in titanium coordination sphere was reported and its biological significance was evaluated. The in vitro cytotoxicity of L1 and 2 were evaluated by using MTT assay on cancer cell lines (MCF-7 & A549) and observed significant cytotoxicity. Further, the LDH and NO assay studies on both L1 and 2 on cancer cell lines revealed that the enhanced cytotoxicity compared to standard anticancer drug i.e. cisplatin. The DNA binding studies of tested compounds with Ct-DNA molecule by using UV-visible and fluorescence spectra and molecular docking studies revealed that moderate to good binding interactions with test molecules. Thus, the present work contributes and implies the biological significance of Ti-complex (2) and the correlation between the structure and the biological activities of such Ti-complexes supported by Schiff base systems opens up opportunities for further exploitation of similar biologically active titanium systems.