Gallic Acid Ameliorates Bisphenol A-Induced Toxicity in Wistar Rats
- Resource Type
- Authors
- S. G. Olukole; Damilare Olaniyi Lanipekun; Eunice Olufunke Ola-Davies
- Source
- Iranian Journal of Toxicology, Vol 12, Iss 4, Pp 11-18 (2018)
- Subject
- 0301 basic medicine
endocrine system
Bisphenol A
Toxicity
Gallic acid
urogenital system
Health, Toxicology and Mutagenesis
010501 environmental sciences
Pharmacology
Kidney
Toxicology
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
Liver
chemistry
lcsh:RA1190-1270
hormones, hormone substitutes, and hormone antagonists
lcsh:Toxicology. Poisons
0105 earth and related environmental sciences
- Language
- ISSN
- 2251-9459
2008-2967
Background: Bisphenol A (BPA) has received attention in environmental and toxicological research due to its widespread effects in biological systems. While several anti-oxidants have been used in ameliorating BPA-induced toxicities in experimental animals, there is the scarcity of research information on the use of Gallic acid (GA) in protecting against BPA-induced toxicity. This study investigated the ameliorative effect of Gallic acid in BPA-induced toxicities of the adult male Wistar rats. Methods: Thirty two adult male Wistar rats were randomly assigned into four groups of eight animals each as follows: Group 1 (Control rats): 0.2 ml of corn oil; Group 2 (GA-treated rats): 20 mg/kg/day GA (dissolved in distilled water); Group 3 (BPA-treated rats): 10 mg/kg/day BPA suspended in 0.2 ml corn oil; Group 4 (BPA+GA-treated rats): BPA (10 mg/kg/day) with a concomitant GA (20 mg/kg/day). All treatments were orally administered for 14 days. Results: BPA significantly increased (P