Immunodeficiency syndrome in a Weimaraner involving the peripheral nervous system
- Resource Type
- Authors
- M. Lowrie; S. Cuthbert; M. Morton
- Source
- Veterinary Record Case Reports. 4
- Subject
- medicine.medical_specialty
Pathology
Neurology
General Veterinary
medicine.diagnostic_test
040301 veterinary sciences
business.industry
Neurological examination
Physical examination
04 agricultural and veterinary sciences
medicine.disease
0403 veterinary science
Immunodeficiency Syndrome
03 medical and health sciences
0302 clinical medicine
Hypertrophic osteodystrophy
medicine
Polyarthritis
Vasculitis
business
030217 neurology & neurosurgery
Immunodeficiency
- Language
- ISSN
- 2052-6121
An 11-week-old male entire Weimaraner presented with a five-day history of pyrexia and pain. Onset of clinical signs developed within five days of routine second vaccination with a modified live multivalent vaccination. General clinical examination identified a diffuse swelling across the muzzle indicative of vasculitis and concurrent blepharoconjunctivitis. Orthopaedic examination demonstrated pain and swelling in multiple joints of both thoracic and pelvic limbs. Neurological examination demonstrated ambulatory flaccid tetraparesis with decreased segmental spinal reflexes indicating a diffuse neuromuscular localisation. Immunoglobulin (IgG, IgM and IgA) analysis was performed, suggesting an inherited immunodeficiency. Radiographs of multiple joints confirmed bilateral effusions and evidence of hypertrophic osteodystrophy, also known as metaphyseal osteopathy. Joint taps suggested the presence of polyarthritis with neutrophilic inflammation. Electrodiagnostics supported a polyradiculoneuritis. Immunosuppressive prednisolone was administered and a full recovery was achieved. This is the first report of peripheral nervous system involvement in a dog with immunodeficiency.