Outcomes following calcium channel blocker exposures reported to a poison information center
- Resource Type
- Authors
- Kasper Meidahl Petersen; Kim Dalhoff; Espen Jimenez-Solem; Tonny Studsgaard Petersen; Søren Bøgevig; Mikkel B. Christensen; Jon Trærup Andersen; Salam Al-Gibouri
- Source
- BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-8 (2018)
Christensen, M B, Petersen, K M, Bøgevig, S, Al-Gibouri, S, Jimenez-Solem, E, Dalhoff, K P, Petersen, T S & Andersen, J T 2018, ' Outcomes following calcium channel blocker exposures reported to a poison information center ', B M C Clinical Pharmacology, vol. 19, no. 1, 78, pp. 1-8 . https://doi.org/10.1186/s40360-018-0271-9
BMC Pharmacology & Toxicology
- Subject
- Male
Denmark
Poison control
Suicide, Attempted
Calcium channel blocker
Nitrendipin
Occupational safety and health
Diltiazem
Lacidipin
0302 clinical medicine
Medication Errors
Pharmacology (medical)
030212 general & internal medicine
Child
Aged, 80 and over
Poisoning
Nimodipin
Middle Aged
Hospitalization
Lercanidipin
Child, Preschool
Female
medicine.symptom
Research Article
medicine.drug
Adult
Bradycardia
medicine.medical_specialty
Poison Control Centers
Adolescent
medicine.drug_class
Overdose
Calcium antagonist
Young Adult
03 medical and health sciences
lcsh:RA1190-1270
Injury prevention
medicine
Humans
Amlodipine
Felodipin
Medical prescription
Nifedipin
Aged
lcsh:Toxicology. Poisons
Pharmacology
business.industry
lcsh:RM1-950
Infant, Newborn
Infant
030208 emergency & critical care medicine
Amlodipin
lcsh:Therapeutics. Pharmacology
Isradipin
Calcium channel blockers
Verapamil
Emergency medicine
Drug Overdose
business
- Language
- English
- ISSN
- 2050-6511
BACKGROUND: Calcium channel blockers (CCBs) are widely used drugs that have a narrow therapeutic index. Even minor overdoses must be treated in-hospital due to the risk of severe hypotension and bradycardia. We aimed to describe trends in CCB use and overdoses in Denmark.METHODS: Data on enquiries concerning CCBs reported to the Danish Poisons Information Center (DPIC) from January 2009 to January 2015 was coupled with data on hospitalization and mortality obtained from Danish National Registers. We obtained data on the general use of CCBs in Denmark and retrieved medical charts on fatal cases.RESULTS: From a total of 126,987 enquiries to the DPIC in 2009-2014 we identified 339 CCB unique exposures (3‰ of all). Children CONCLUSION: Four fifths of enquiries to the DPIC result in hospitalization and one fifth concern small children. Mortality were infrequent and occurred only in adults with suicidal exposures and with and an overrepresentation of verapamil exposures.