Ignition sequence start: epithelial allergen sensing and regulation of the allergic inflammatory response
- Resource Type
- Authors
- Ryan C. Murphy; Matthew C. Altman
- Source
- Nature Immunology. 22:1207-1209
- Subject
- Allergy
Chemistry
Inflammatory response
Immunology
Ripoptosome
Interleukin
respiratory system
medicine.disease_cause
medicine.disease
respiratory tract diseases
Cell biology
Allergen
immune system diseases
Allergic response
otorhinolaryngologic diseases
medicine
Immunology and Allergy
Intracellular
- Language
- ISSN
- 1529-2916
1529-2908
Environmental allergens trigger activation of the ripoptosome in epithelial cells, which mediates the initial allergic response via intracellular processing and release of the alarmin IL-33 and represents a newly identified mechanism for epithelial allergen sensing.