Synthesis of Tetrasubstituted Symmetrical Pyrazines from β-Keto γ-Amino Esters: A Mild Strategy for Self-Dimerization of Peptides
- Resource Type
- Authors
- Mothukuri Ganesh Kumar; Rupal D. Bhaisare; Anindita Adak; Varsha J. Thombare; Hosahudya N. Gopi
- Source
- European Journal of Organic Chemistry. 2015:135-141
- Subject
- chemistry.chemical_classification
Amino esters
Chemistry
Stereochemistry
Organic Chemistry
Physical and Theoretical Chemistry
Amino acid
- Language
- ISSN
- 1434-193X
A facile synthesis of highly symmetrical tetrasubstituted pyrazines through simple aerial oxidation of β-keto γ-amino esters is reported. The scope of the reaction was examined by use of various amino acid side-chain functional groups and peptides. The mild and efficient transformation of β-keto γ-amino esters into pyrazines may serve as an attractive strategy for self-dimerization of peptides.