Mild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine‐Based Palladacycle
- Resource Type
- Authors
- Xaiohan Li; Ruchita R. Thakore; Gianluca Casotti; Fabrice Gallou; Balaram S. Takale; Bruce H. Lipshutz
- Source
- Angewandte Chemie International Edition. 60:4158-4163
- Subject
- Green chemistry
Aqueous solution
010405 organic chemistry
Aryl
chemistry.chemical_element
General Chemistry
Nanoreactor
010402 general chemistry
01 natural sciences
Medicinal chemistry
Catalysis
0104 chemical sciences
Stille reaction
chemistry.chemical_compound
chemistry
Triphenylphosphine
Palladium
- Language
- ISSN
- 1521-3773
1433-7851
An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst, leading to highly effective Stille cross-coupling reactions in water under mild reaction conditions. Only 500-1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij-30 in water.