Acute and Late Toxicity after Three-Dimensional Conformal Image-Guided Radiotherapy for Localized Prostate Cancer
- Resource Type
- Authors
- Rosaria Barbarino; Alessandra Carosi; Riccardo Santoni; Alessandra Murgia; Gianluca Ingrosso; Michaela Benassi; Pierluigi Bove; Elisabetta Ponti; Luana Di Murro; Emilia Giudice; Daniela di Cristino
- Source
- Cancer Investigation. 32:526-532
- Subject
- Male
Bladder & prostate cancer
Oncology
Imaging
Late effects of therapy
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Aged
Aged, 80 and over
Cone-Beam Computed Tomography
Disease-Free Survival
Dose Fractionation
Humans
Middle Aged
Prostatic Neoplasms
Radiotherapy, Conformal
Radiotherapy, Image-Guided
Treatment Outcome
Image guided radiotherapy
Late toxicity
Prostate cancer
Settore MED/36 - Diagnostica per Immagini e Radioterapia
Internal medicine
80 and over
Medicine
Radiotherapy
Conformal
Genitourinary system
business.industry
General Medicine
prostate cancer
Tumor control
medicine.disease
Radiation therapy
Bladder &
Image-Guided
Total dose
Toxicity
Dose Fractionation, Radiation
Radiology
business
- Language
- ISSN
- 1532-4192
0735-7907
We evaluated the clinical impact of a high definition micro-multileaf collimator and a linac-integrated cone-beam computed tomography in 142 patients treated with conformal radiotherapy for localized prostate cancer to a total dose of 76 Gy. Details on treatment toxicity and tumour control were collected. The 3 years biochemical relapse-free survival was 90%. Acute and late gastrointestinal toxicities were low (3-year actuarial late toxicity of 11.2%). Acute genitourinary toxicity was relatively high, the 3-year actuarial genitourinary late toxicity was 12%. Conformal image-guided radiotherapy for localized prostate cancer leads to low rates of late toxicity with a high rate of tumor control.