C-reactive protein responsein utero
- Resource Type
- Authors
- Rosalinde Hurley; D. R. Harvey; J. de Louvois; J. Skingle
- Source
- Journal of Obstetrics and Gynaecology. 10:367-372
- Subject
- Fetus
medicine.medical_specialty
Pregnancy
Amniotic fluid
biology
medicine.diagnostic_test
business.industry
Obstetrics
C-reactive protein
Obstetrics and Gynecology
Gestational age
medicine.disease
Andrology
Fetoscopy
In utero
biology.protein
Medicine
Gestation
business
- Language
- ISSN
- 1364-6893
0144-3615
SummaryC-reactive protein concentration was determined by enzyme immunoassay in fetal serum (gestational ages 15–38 weeks) from a group of 91 patients undergoing fetoscopy. Matched amniotic fluid or maternal serum samples were obtained from the majority of these patients. C-reactive protein levels were also determined in 90 cord serum samples (gestational ages 29–42 weeks) from uneventful deliveries, forceps deliveries, caesarean sections and vaginal deliveries where maternal pyrexia was recorded.C-reactive protein concentration ranged from > 10–200 μg/1 in 91 per cent of fetal and cord serum samples. The protein is present in fetal serum as early as 15 weeks of gestational age. In fetuses > 20 weeks, 50 per cent had serum levels < 10 μg/1 and 36 per cent had serum levels < 200 μg/1. Throughout pregnancy the fetus can produce an apparently independent C-reactive protein response following intra-uterine stimulation. Raised fetal levels are associated with both raised amniotic fluid and raised maternal seru...