Conventional Method of Transverse Aortic Constriction in Mice
- Resource Type
- Authors
- Jimeen, Yoo; Vadim, Chepurko; Roger J, Hajjar; Dongtak, Jeong
- Source
- Methods in molecular biology (Clifton, N.J.). 1816
- Subject
- Heart Failure
Male
Disease Models, Animal
Mice
Microsurgery
Echocardiography
Systole
Heart Ventricles
Disease Progression
Animals
Cardiomegaly
Constriction
Aorta
- Language
- ISSN
- 1940-6029
Transverse aortic constriction is a widely used surgical model to reflect the progression from cardiac hypertrophy to heart failure states due to left ventricular pressure overload in mice. It produces afterload increase on the left ventricle in which compensated hypertrophy initially occurs in the first 2 weeks. This develops into maladaptive remodeling of the left ventricle and atrium, leading to heart failure. This model is useful for cardiac studies since transverse aortic constriction can be consistently replicated and has low surgical mortality. Additionally, the gradual progression to cardiac failure makes it a valuable method to evaluate the efficacy of potential therapeutic intervention. We introduce this chapter to offer practical approaches to facilitate a simple methodology for transverse aortic constriction.