Cytomegalovirus Seropositivity is Associated with Airflow Limitation in a Cohort of Veterans with a High Prevalence of Smoking
- Resource Type
- Authors
- Timothy Hwalek; Andrew R. Osterburg; Ralph J. Panos; Robert M. Burkes; Laura Lach; Michael T. Borchers
- Source
- Chronic Obstr Pulm Dis
- Subject
- Pulmonary and Respiratory Medicine
Vital capacity
COPD
Cellular immunity
medicine.medical_specialty
business.industry
virus diseases
Logistic regression
medicine.disease
Origianl Research
respiratory tract diseases
Chronic infection
Internal medicine
Cohort
medicine
Avidity
Serostatus
business
- Language
- English
Background: Cytomegalovirus (CMV) represents an understudied chronic infection, usually contracted early in life, that causes chronic immune system alterations which may contribute to airflow limitations in a cohort of veterans with a high prevalence of smoking. We studied 172 participants at-risk for and with airflow limitation with available CMV serology to assess the relationship between CMV infection and chronic obstructive pulmonary disease (COPD)-related outcomes. Methods: The study cohort includes 172 veterans who are smokers with or at risk for the development of COPD. Clinical data were obtained by chart abstraction at enrollment. CMV affinity (ever-exposure) and avidity testing (length of exposure) were performed on plasma samples collected at enrollment. Bivariable and multivariable logistic regression was used to determine the relationship between both cytomegalovirus affinity and avidity and odds of prevalent airflow limitation (post-bronchodilator forced expiratory volume in 1 second to forced vital capacity ratio