Simultaneous
- Resource Type
- Authors
- Muhummad Sohaib, Nazir; Sarah-May, Gould; Xenios, Milidonis; Eliana, Reyes; Tevfik F, Ismail; Radhouene, Neji; Sébastien, Roujol; Jim, O'Doherty; Hui, Xue; Sally F, Barrington; Tobias, Schaeffter; Reza, Razavi; Paul, Marsden; Peter, Kellman; Sven, Plein; Amedeo, Chiribiri
- Source
- European Journal of Hybrid Imaging
- Subject
- Myocardial perfusion
Hybrid imaging
PET-MR
Original Article
Myocardial blood flow
circulatory and respiratory physiology
- Language
- ISSN
- 2510-3636
Background Positron emission tomography (PET) is the non-invasive reference standard for myocardial blood flow (MBF) quantification. Hybrid PET-MR allows simultaneous PET and cardiac magnetic resonance (CMR) acquisition under identical experimental and physiological conditions. This study aimed to determine feasibility of simultaneous 13N-Ammonia PET and dynamic contrast-enhanced CMR MBF quantification in phantoms and healthy volunteers. Methods Images were acquired using a 3T hybrid PET-MR scanner. Phantom study: MBF was simulated at different physiological perfusion rates and a protocol for simultaneous PET-MR perfusion imaging was developed. Volunteer study: five healthy volunteers underwent adenosine stress. 13N-Ammonia and gadolinium were administered simultaneously. PET list mode data was reconstructed using ordered subset expectation maximisation. CMR MBF was quantified using Fermi function-constrained deconvolution of arterial input function and myocardial signal. PET MBF was obtained using a one-tissue compartment model and image-derived input function. Results Phantom study: PET and CMR MBF measurements demonstrated high repeatability with intraclass coefficients 0.98 and 0.99, respectively. There was high correlation between PET and CMR MBF (r = 0.98, p