University of Maryland Schools of Nursing, Pharmacy and Social Work faculty partnered with three local safety net clinics to develop biweekly, faculty-precepted, student-led interprofessional team care clinics to enhance primary care for patients with complex medical and/or psychosocial conditions. Over two years, fifty patients with diabetes mellitus received interprofessional care and experienced an average decrease in hemoglobin A1c of 2.2% from baseline, a clinically meaningful and statistically significant improvement. Mean systolic blood pressure also decreased significantly, and emergency department visits decreased by 75% in the six months post-participation. A sub-group of patients also experienced significant reductions in Patient Health Questionnaire scores. Improvements in diastolic blood pressure, cholesterol levels, and body mass index were not statistically significant. Academic practice partnerships can facilitate new team-based models of care that contribute to improved patient outcomes and reduced costs of care. However, developing effective faculty-precepted, student-led interprofessional care is challenging, requiring planning and coordination.