Transport-driven engineering of liposomes for delivery of α-particle radiotherapy to solid tumors: effect on inhibition of tumor progression and onset delay of spontaneous metastases
- Resource Type
- Authors
- George Sgouros; Stavroula Sofou; Omkar Bhatavdekar; Dominick Salerno; Alaina Howe; Aprameya Prasad; Rajiv Nair; Michelle Sempkowski; Kathleen L. Gabrielson; Jesus Pacheco-Torres; Zaver M. Bhujwalla; Anders Josefsson
- Source
- European Journal of Nuclear Medicine and Molecular Imaging. 48:4246-4258
- Subject
- medicine.medical_treatment
Antineoplastic Agents
Triple Negative Breast Neoplasms
030218 nuclear medicine & medical imaging
Metastasis
Mice
03 medical and health sciences
0302 clinical medicine
Cell Line, Tumor
medicine
Animals
Humans
Cytotoxic T cell
Radiology, Nuclear Medicine and imaging
Triple-negative breast cancer
Liposome
Chemistry
General Medicine
Alpha Particles
medicine.disease
Radiation therapy
Tumor progression
030220 oncology & carcinogenesis
Liposomes
Cancer research
Nanocarriers
α particles
- Language
- ISSN
- 1619-7089
1619-7070
Highly cytotoxic α-particle radiotherapy delivered by tumor-selective nanocarriers is evaluated on metastatic Triple Negative Breast Cancer (TNBC). On vascularized tumors, the limited penetration of nanocarriers (