OBSOLETE: Animal Models of Ischemic Heart Disease: From Atherosclerosis and Thrombosis to Myocardial Infarction
- Resource Type
- Authors
- R. Covarrubias; A.S. Major; R.J. Gumina
- Source
- Subject
- medicine.medical_specialty
Myocardial ischemia
business.industry
Inflammation
Disease
medicine.disease
Thrombosis
Increased lipid
Internal medicine
Heart failure
medicine
Cardiology
Myocardial infarction
medicine.symptom
Ischemic heart
business
- Language
Coronary heart disease is a complex human pathologic condition that is predominated by atherosclerosis. The development of atherosclerosis in the vasculature involves increased lipid accumulation in the artery walls as well as chronic inflammation propagated by a variety of cell types. The potentially fatal or debilitating effects of atherosclerosis are due to the rupture of unstable plaques and the subsequent thrombosis of epicardial vessels. This acute thrombosis leads to myocardial ischemia and subsequent myocardial infarction if not treated promptly with reperfusion therapies. This chapter reviews the various animal models that are available to study atherosclerosis, thrombosis, and myocardial ischemia-reperfusion injury and infarction-induced heart failure.