Intravoxel incoherent motion diffusion-weighted imaging for discrimination of benign and malignant retropharyngeal nodes
- Resource Type
- Authors
- Ann D. King; Sahrish Qamar; Tiffany Y. So; K.C. Allen Chan; Edwin P. Hui; Frankie Mo; Darren M.C. Poon; W K Jacky Lam; Qi-Yong H. Ai
- Source
- Neuroradiology. 62(12)
- Subject
- Adult
Male
Retropharyngeal nodes
Contrast Media
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Meglumine
Image Interpretation, Computer-Assisted
Organometallic Compounds
Medicine
Effective diffusion coefficient
Humans
Radiology, Nuclear Medicine and imaging
Head and neck
Intravoxel incoherent motion
Neuroradiology
Aged
Retrospective Studies
Nasopharyngeal Carcinoma
business.industry
Bayes Theorem
Middle Aged
medicine.disease
Diffusion Magnetic Resonance Imaging
Nasopharyngeal carcinoma
Lymphatic Metastasis
Mann–Whitney U test
Female
Neurology (clinical)
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
030217 neurology & neurosurgery
Diffusion MRI
- Language
- ISSN
- 1432-1920
Anatomical imaging criteria for the diagnosis of malignant head and neck nodes may not always be reliable. This study aimed to evaluate the diagnostic value of conventional diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) DWI in discriminating benign and malignant metastatic retropharyngeal nodes (RPNs). IVIM DWI using 14 b-values was performed on RPNs of 30 patients with newly diagnosed metastatic nasopharyngeal carcinoma (NPC) and 30 patients with elevated plasma Epstein-Barr virus (EBV)-DNA without NPC who were part of an EBV-based NPC screening program. Histogram measurements of the two groups were compared for pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion volume fraction (f) and apparent diffusion coefficient (ADC) using the Mann-Whitney U test. Area under the curves (AUCs) of significant measurements were calculated from receiver-operating characteristics analysis and compared using the DeLong test. Compared with metastatic RPNs, benign RPNs had lower ADCmean (0.73 vs 0.82 × 10−3 mm2/s) and Dmean (0.60 vs 0.71 × 10−3 mm2/s) and a higher D*mean (35.21 vs 28.66 × 10−3 mm2/s) (all p