A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent
- Resource Type
- Authors
- Gajalakshmi Singuru; Sridhar Reddy Maddi; Praveen Kumar Neeli; Sravya Panangipalli; Rajkumar Banerjee; Surendar Reddy Bathula; Srigiridhar Kotamraju; Rajamannar Thennati; Altab Shaikh
- Source
- Chemical communications (Cambridge, England). 57(92)
- Subject
- Small interfering RNA
Excipient
Catalysis
chemistry.chemical_compound
Cell Line, Tumor
Self assembling
Amphiphile
Materials Chemistry
medicine
Humans
Phosphonium
Umbelliferones
RNA, Small Interfering
reproductive and urinary physiology
RNA, Double-Stranded
urogenital system
Chemistry
Metals and Alloys
General Chemistry
Small molecule
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Cell biology
Mitochondria
embryonic structures
Ceramics and Composites
Breast cancer cells
biological phenomena, cell phenomena, and immunity
medicine.drug
- Language
- ISSN
- 1364-548X
Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as functionally active and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induces selective breast cancer cell death, the amphiphilic nature of Mito-Esc delivers therapeutic siRNAs intracellularly without the need for any excipient to exacerbate the anti-proliferative effects.