Background The University of Texas Wound Classification is a tool assesing risk of amputation of patients with Diabetic Foot Ulceration (DFU). Negative Pressure Wound Therapy (NPWT) is a nonivasive system which was shown to be effective in healing chronic wounds. The aim of the study was to assess utility of long-term NPWT in healing diabetic foot wounds among Polish patients with diabetes. Material & Methods In the study, we retrospectively analysed data of patients of DFU ambulatory using NPWT. Collected data included sex, age, type of DFU, duration of NPWT, history of previous minor amputation and characteristic of the healed wound in The University of Texas Wound Classification before and after NPWT. Results Total number of participants counted 21 (male = 16, 76%). The wound significantly improved in 17 (81%) patients. Group with successful treatment reached median 92% decrease of risk of amputation (-8.5 to -92%; p Conclusions NPWT significantly decraeses risk of amputation in Texas Score. NPWT may not help in healing wounds simultaneously infected and ischeamic. Presence of ischemic wound decreases chance for successful outcome.