Influence of the presence of a methyl group on the myocardial metabolism of 15-(paraiodophenyl)-3 methyl pentadecanoic acid (IMPPA)
- Resource Type
- Authors
- Xavier Leverve; Thierry Humbert; Danièle Marti Batlle; Pierre Cuchet; Christiane Keriel; M. Comet; Cuong Luu-Duc
- Source
- International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1990, 17 (8), pp.745-9
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, Elsevier, 1990, 17 (8), pp.745-9
- Subject
- Saccharomyces cerevisiae Proteins
MESH: Myocardium
MESH: Rats
chemistry.chemical_element
In Vitro Techniques
030204 cardiovascular system & hematology
Pentadecanoic acid
MESH: Iodobenzenes
Iodine
030218 nuclear medicine & medical imaging
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
MESH: Saccharomyces cerevisiae Proteins
Coenzyme A Ligases
Animals
MESH: Animals
Carbon Radioisotopes
MESH: Carbon Radioisotopes
MESH: Coenzyme A Ligases
Iodobenzenes
Myocardial metabolism
Myocardium
Fatty Acids
Rats, Inbred Strains
General Medicine
Metabolism
MESH: Rats, Inbred Strains
Rats
MESH: Fatty Acids
Repressor Proteins
chemistry
Biochemistry
MESH: Repressor Proteins
Female
Perfusion
MESH: Female
Intracellular
Methyl group
- Language
- English
- ISSN
- 0883-2897
International audience; The objective of the present study was to determine the mechanism of accumulation of myocardial activity following i.v. injection of 15-(paraiodophenyl)-3 methyl pentadecanoic acid (IMPPA). IMPPA and 15 phenyl-3 methyl pentadecanoic acid (MPPA) were labeled with 14C at position 1 and used to perfuse isolated rat hearts in a closed system. After 5 min of perfusion, IMPPA reached 2/3 of its value at 45 min. 14CO2 production was low. Most of the myocardial activity was in the form of free IMPPA. Analysis of IMPPA activation by CoA SH revealed that it was very strongly inhibited. The retention of myocardial activity is thus due to intracellular accumulation of free IMPPA following inhibition of activation. Comparison of results obtained with IMPPA and MPPA showed that the presence of iodine in the molecule accentuates the inhibition of activation.