Bis-homo avermectin B1a - A semi-synthetic analog with a trienic 18-membered macrocyclic ring
- Resource Type
- Authors
- Yongxue Tu; Philippe Chemla; Stephen Hanessian
- Source
- Tetrahedron Letters. 34:1407-1410
- Subject
- Avermectin B1a
chemistry.chemical_classification
chemistry.chemical_compound
chemistry
Stereochemistry
Organic Chemistry
Drug Discovery
Acetal
Ring (chemistry)
Biochemistry
Lactone
Semi synthetic
- Language
- ISSN
- 0040-4039
The title compound was synthesized from semi-synthetic subunits obtained from avermectin B1a after homologation, coupling, lactonization and deconjugation.