Self-Assembly of an Antiangiogenic Nanofibrous Peptide Hydrogel
- Resource Type
- Authors
- Vivek A. Kumar; Soo Jin Kim; Eun Jung Lee; Rachapudi Sruti; William Gao; Michael McGowan; Peter K. Nguyen; Biplab Sarkar; Patricia Iglesias-Montoro; Zain Siddiqui
- Source
- ACS applied bio materials. 1(3)
- Subject
- chemistry.chemical_classification
Scaffold
Biocompatibility
medicine.drug_class
Biochemistry (medical)
Biomedical Engineering
In vitro toxicology
Peptide
macromolecular substances
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
Monoclonal antibody
01 natural sciences
0104 chemical sciences
Biomaterials
chemistry
Target site
In vivo
Nanofiber
medicine
Cancer research
0210 nano-technology
- Language
- ISSN
- 2576-6422
Pathological neovascularization may cause or worsen intraocular posterior segment diseases such as diabetic retinopathy. Prevention of aberrant vascularization is thus an important clinical target. Therapeutic antiangiogenic agents are generally used in diffusible monomeric formulation (e.g., injection of anti-VEGF monoclonal antibodies into the vitreous humor). Here, we report the attachment of a therapeutic antiangiogenic motif to a fibrillizing peptide backbone that undergoes nanofibrous self-assembly into an injectable hydrogel. The peptide can persist for extended periods in a target site, prolonging the therapeutic time frame. The injectability of the hydrogel was investigated through rheometric characterization. Biophysical characterization was complemented by in vitro assays to test the antiangiogenic capability of the scaffold. We also tested persistence and biocompatibility of the hydrogel through in vivo implantation. This injectable hydrogel therapy may unlock potential clinical routes for tre...