Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival
- Resource Type
- Authors
- Chakravarthi Rajkumar; David Chadwick; Mark Wilks; Christopher I. Jones; Laura Behar; Angela Whiley; Paula Sharratt; Angela Dunne; Philip Stanley; Claire Proctor; Martin J. Llewelyn
- Source
- The Journal of Infection
- Subject
- Diarrhea
Male
Colonization
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Bacterial Toxins
030106 microbiology
Logistic regression
Polymerase Chain Reaction
Ribotyping
Article
Enterotoxins
Feces
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Prospective Studies
030212 general & internal medicine
Intensive care medicine
Aged, 80 and over
Cross Infection
Clostridioides difficile
Transmission (medicine)
business.industry
Clostridium difficile
medicine.disease
Anti-Bacterial Agents
Hospitalization
Malnutrition
Logistic Models
Infectious Diseases
England
Risk factors
Toxin detection
Clostridium Infections
Female
Observational study
business
- Language
- ISSN
- 0163-4453
Summary Objectives To establish risk factors for Clostridium difficile colonization among hospitalized patients in England. Methods Patients admitted to elderly medicine wards at three acute hospitals in England were recruited to a prospective observational study. Participants were asked to provide a stool sample as soon as possible after enrolment and then weekly during their hospital stay. Samples were cultured for C. difficile before ribotyping and toxin detection by PCR. A multivariable logistic regression model of risk factors for C. difficile colonization was fitted from univariable risk factors significant at the p
Highlights • Hospitalized adults in our study were commonly colonized by toxigenic Clostridium difficile. • Risk factors for colonization were previous active C. difficile infection, high risk of malnutrition assessed by Malnutrition Universal Screening Tool score ≥2. • Patients colonized by C. difficile were at increased risk of death at 90 days. • C. difficile colonization was not of itself a risk factor for death at 90 days.