The epithelial–mesenchymal transition in cancer: a potential critical topic for translational proteomic research
- Resource Type
- Authors
- Maria Antonietta Isgrò; Patrizia Bottoni; Roberto Scatena
- Source
- Expert Review of Proteomics. 13:115-133
- Subject
- Proteomics
cancer stem cells
0301 basic medicine
Pathology
medicine.medical_specialty
Epithelial-Mesenchymal Transition
Carcinogenesis
Gene Expression
Biology
medicine.disease_cause
Biochemistry
Translational Research, Biomedical
03 medical and health sciences
Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
Circulating tumor cell
Cancer stem cell
Neoplasms
Biomarkers, Tumor
medicine
Animals
Humans
Epithelial–mesenchymal transition
Settore BIO/10 - BIOCHIMICA
Molecular Biology
Settore MED/06 - ONCOLOGIA MEDICA
Cancer
medicine.disease
Gene Expression Regulation, Neoplastic
030104 developmental biology
Tumor progression
embryonic structures
Cancer cell
Neoplastic Stem Cells
Cancer research
- Language
- ISSN
- 1744-8387
1478-9450
The epithelial-mesenchymal transition (EMT) is a morphogenetic process that results in a loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. First described in embryogenesis, the EMT has been recently implicated in carcinogenesis and tumor progression. In addition, recent evidence has shown that stem-like cancer cells present the hallmarks of the EMT. Some of the molecular mechanisms related to the interrelationships between cancer pathophysiology and the EMT are well-defined. Nevertheless, the precise molecular mechanism by which epithelial cancer cells acquire the mesenchymal phenotype remains largely unknown. This review focuses on various proteomic strategies with the goal of better understanding the physiological and pathological mechanisms of the EMT process.