Doppler echocardiographic assessment and cardiac gene expression analysis of the left ventricle in myocardial infarcted rats
- Resource Type
- Authors
- Junichi Yoshikawa; Minoru Yoshiyama; Akihisa Hanatani; Naruhito Shimizu; Hiroshi Iwao; Shokei Kim; Kazuhide Takeuchi; Takashi Omura
- Source
- Japanese circulation journal. 62(6)
- Subject
- Fetal Proteins
Male
medicine.medical_specialty
Physiology
Heart Ventricles
Diastole
Myocardial Infarction
Hemodynamics
Muscle Proteins
Doppler echocardiography
Ventricular Dysfunction, Left
Atrial natriuretic peptide
Transforming Growth Factor beta
Internal medicine
medicine
Myocyte
Animals
Myocardial infarction
RNA, Messenger
Rats, Wistar
Fetus
medicine.diagnostic_test
Myosin Heavy Chains
business.industry
Myocardium
Metalloendopeptidases
medicine.disease
Actins
Echocardiography, Doppler
Rats
medicine.anatomical_structure
Endocrinology
Phenotype
Gene Expression Regulation
Ventricle
Echocardiography
Gelatinases
cardiovascular system
Cardiology
Matrix Metalloproteinase 2
Hypertrophy, Left Ventricular
Collagen
Cardiology and Cardiovascular Medicine
business
Atrial Natriuretic Factor
- Language
- ISSN
- 0047-1828
The purpose of this study was to examine cardiac geometry and function by Doppler echocardiography and to analyze mRNA expression of cardiac phenotype and extracellular matrix in myocardial infarcted rats. Doppler echocardiograms and hemodynamics were measured 2 weeks after myocardial infarction (MI). mRNA levels in the non-infarcted left ventricle (LV) and infarct site were measured by Northern blot analysis. LV internal diastolic dimension was greater in infarcted (MI) than in sham-operated rats (control) (MI 7.2+/-0.3 mm vs control 4.6+0.3 mm, p