The efficiency of continuous positive airway pressure therapy in carbon monoxide poisoining in the emergency department
- Resource Type
- Authors
- Murat Doğan İşcanlı; Fevzi Yilmaz; Uğur Bal; Selim Inan; Bedriye Müge Sönmez
- Source
- European Journal of Emergency Medicine. 27:217-222
- Subject
- medicine.medical_treatment
030204 cardiovascular system & hematology
Teaching hospital
Carbon Monoxide Poisoning
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Primary outcome
Oxygen therapy
medicine
Humans
Continuous positive airway pressure
Carbon Monoxide
Continuous Positive Airway Pressure
business.industry
Carbon monoxide poisoning
030208 emergency & critical care medicine
Emergency department
medicine.disease
respiratory tract diseases
Carboxyhemoglobin
chemistry
Anesthesia
Emergency Medicine
Emergency Service, Hospital
business
Carbon monoxide
- Language
- ISSN
- 0969-9546
Objective To determine whether oxygen therapy with continuous positive airway pressure (CPAP) is superior to normobaric oxygen therapy in carbon monoxide poisoning. Methods The study participants were 43 patients diagnosed with carbon monoxide poisoning between the dates 15 March and 30 June 2016 at the emergency department of an urban teaching hospital. The control group comprised patients who received normobaric oxygen therapy. The case group consisted of patients who underwent one-hour CPAP therapy. The primary outcome was the determination of the half-life of carboxyhemoglobin (COHb) with CPAP treatment. The CPAP and control groups were compared in terms of the reduction in COHb levels after 60 minutes of therapy. Results The COHb level among patients in the CPAP group was lower in the 30th and 60th minutes. The half-life of COHb was apparently decreased in the CPAP group compared with the control group (control and case groups mean plasma half-life of COHb were 80.26 ± 12.70 and 36.20 ± 4.58 minutes, respectively). Conclusion The results of the present study demonstrate that CPAP therapy may be an effective option for oxygen therapy among patients with carbon monoxide intoxication; this is achieved by decreasing the half-life of COHb.