Monitoring and blunting are cognitive-affective informational processing styles that may predict future internalizing symptoms among youths with cystic fibrosis (CF). Forty-four youths with CF (9–23 years) and one of their parents completed measures of the youths’ monitoring, blunting, and internalizing symptoms at baseline and again two years later. Monitoring was associated with higher levels of concurrent internalizing symptoms on self- but not parent report, and did not predict changes in future symptoms. Blunting, in contrast, predicted a relative decrease in self-reported anxiety and depressive symptoms and in parent-report of youths’ depressive symptoms at Time 2. Our findings suggest that blunting may be an important protective factor in the adjustment of youths with CF.