Exploring the molecular mechanism of azole resistance in Aspergillus fumigatus
- Resource Type
- Authors
- Peiying Chen; Hong Sang; Meihua Zeng; Juan Liu
- Source
- Journal de mycologie medicale. 30(1)
- Subject
- Azoles
0303 health sciences
Antifungal Agents
biology
030306 microbiology
Mechanism (biology)
Antifungal drugs
Aspergillus fumigatus
Azole resistance
High-Throughput Nucleotide Sequencing
Aspergillus infections
Computational biology
Microbial Sensitivity Tests
biology.organism_classification
Fungal Proteins
03 medical and health sciences
Sterol 14-Demethylase
Infectious Diseases
Drug Resistance, Fungal
Gene Expression Regulation, Fungal
Mutation
Molecular mechanism
Aspergillosis
Humans
- Language
- ISSN
- 1773-0449
Aspergillus infections are increasingly recognized as a global health problem because of limited antifungal drugs and occurrence of azole resistance worldwide. More cyp51-mediated and non-cyp51-mediated mechanisms of azole resistance have been identified in clinical and laboratory studies in recent years with applications of molecular biotechnology including next-generation sequencing, reverse genetics and so on. In this review, current research on the molecular mechanisms of azole resistance in A. fumigatus were presented and summarized and meanwhile the putative clinical relevance of these findings from bench work were discussed. Important aims are to gain more insight to mechanism of azole resistance and provide some efficient lead for prevention strategy.