Additional file 1: Fig. S1 Geographical location of the participating intensive care units. Table S1. Repartition of the patients included according to the ICU. Table S2. Characteristics of the ICU. Fig. S2. Thresholds to start, resume or stop insulin. Fig. S3. Standard and lowest intervals between blood glucose tests. Fig. S4. Flow chart. Table S3. Glycemic control. Fig. S5. density of probability of mean individual glycaemia. Table S4. Linear mixed model—Period 1. Table S5. Linear mixed model—Period 2. Fig. S6. Number of blood glucose tests performed on the study day during Period 1 according to the SOFA score. Fig. S7. Number of blood glucose tests performed on the study day during Period 2 according to the SOFA score. Fig. S8. blood glucose value of patient under IV insulin during Period 2 according to the upper limit of the ICU’s blood glucose management protocol. Fig. S9. Individual glucose variability according to the periodand types of insulin used, in all patients. Fig. S10. Individual glucose variability according to the periodand types of insulin used, in patients without diabetes. Fig. S11. Individual glucose variability according to the periodand types of insulin used, in patients with diabetes. Fig. S12. Repartition of the individual glucose variability according to the period, existence of diabetes, and use of subcutaneous insulin, in patients receiving insulin of any type. Fig. S13. Number of blood glucose tests performed according to the number of hypoglycaemias. Fig. S14. Number of blood glucose tests performed according to the number of hyperglycaemias. Table S6. Hyperglycemic events. Table S7. Incidence rate ratio of hyperglycemia. Table S8. Incidence rate ratio of hyperglycemia. Table S9. Incidence rate ratio of hyperglycemia