Cysteinyl-maresins, also known as maresin-conjugates in tissue regeneration (MCTRs), are recently discovered lipid mediators proposed to reduce airway inflammation.To investigate the influence of MCTRs on IL-13-induced airway hyperresponsiveness in isolated human and mice airways.Before responsiveness to contractile agonists were assessed in myographs, human small bronchi were cultured for 2 days and mouse tracheas were cultured for 1-4 days. During the culture procedure airways were exposed to interleukin (IL)-13 in the presence or absence of MCTRs. Signalling mechanisms were explored using pharmacologic agonists and antagonists, and genetically modified mice.IL-13 treatment increased contractions to histamine, carbachol and leukotriene DMCTR3, but not LTD