Mannose binding lectin-associated serine protease 2 (MASP2) gene polymorphism and susceptibility to human T-lymphotropic virus type 1 (HTLV-1) infection in blood donors from Mashhad, Iran
- Resource Type
- Authors
- Akram Aghamohammadi; Houshang Rafatpanah; Mahtab Maghsoodlu; Nastaran Tohidi; Farzad Mollahosseini; Majid Shahabi
- Source
- Microbiology and immunologyREFERENCES. 66(10)
- Subject
- Human T-lymphotropic virus 1
Genotype
Immunology
Blood Donors
Iran
Microbiology
HTLV-I Infections
Polymorphism, Single Nucleotide
Virology
Case-Control Studies
Lectins
Mannose-Binding Protein-Associated Serine Proteases
Humans
Genetic Predisposition to Disease
- Language
- ISSN
- 1348-0421
Mannose binding lectin-associated serine protease 2 (MASP2) is the effector part of mannose binding lectin (MBL) that activates the complement system in an antibody-independent manner. We aimed to investigate the role of genetic polymorphisms in the MASP2 gene and susceptibility to HTLV-1 infection. A total of 172 HTLV-1 infected individuals and 170 healthy blood donors were analyzed in this case-control study. Nine single nucleotide polymorphisms (SNPs) encompassing different regions of the MASP2 gene were genotyped with a polymerase chain reaction-sequence-specific primer (PCR-SSP) assay. The relation between the SNPs genotype and the susceptibility to HTLV-1 infection was investigated with a χ