Excretion of α-ketoglutaric acid during oxidation of acetate by a vibrio
- Resource Type
- Authors
- M.D. Patel; S. Dagley
- Source
- Biochimica et Biophysica Acta. 16:418-423
- Subject
- biology
Chemistry
Oxidation reduction
General Medicine
Acetates
Ketones
biology.organism_classification
Keto Acids
Vibrio
Excretion
Citric acid cycle
Ketoglutaric Acid
Biochemistry
Ketoglutaric Acids
Oxidation-Reduction
- Language
- ISSN
- 0006-3002
Excretion of α-ketoglutaric acid by a vibrio during oxidation of acetate has been established by isolation and characterization of the 2:4-dinitrophenylhydrazone. Cells grown on a wide variety of substrates were able to oxidize acetate but they did not excrete α-ketoglutarate in the process. A mechanism for excretion of this compound developed during growth on acetate and other fatty acids. The necessity for postulating other mechanisms in addition to the tricarboxylic acid cycle is discussed in the light of these observations.