The use of rigid ethanolic solutions for the phosphorimetric investigation of organic compounds of pharmacological interest
- Resource Type
- Authors
- J.D. Winefordner; M. Tin
- Source
- Analytica Chimica Acta. 31:239-245
- Subject
- Detection limit
chemistry.chemical_compound
Ethanol
chemistry
Inorganic chemistry
Biological fluids
Environmental Chemistry
Organic chemistry
Trace analysis
Phosphorescence
Biochemistry
Spectroscopy
Analytical Chemistry
- Language
- ISSN
- 0003-2670
Phosphorescence excitation and emission spectral peaks, lifetimes, working curves and limits of detection of 22 organic compounds of pharmacological importance in rigid (77°K) ethanolic solution are given. Ethanol can be easily prepared in a high degree of purity, and most drugs are much more soluble in ethanol than in most solvents previously used for phosphorimetric studies. The possible application of phosphorimetry to the trace analysis of drugs in biological fluids is discussed.