767 Magnetic Resonance Imaging in the Assessment of Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy: Evaluation of the Prognostic Value of Mid-Chemotherapy and Post-Chemotherapy Scans
- Resource Type
- Authors
- E. Barrett; R Okhiria; M Davenport; Lyndsey Highton
- Source
- British Journal of Surgery. 108
- Subject
- medicine.medical_specialty
Chemotherapy
medicine.diagnostic_test
business.industry
medicine.medical_treatment
Magnetic resonance imaging
medicine.disease
Breast cancer
medicine
Surgery
Radiology
business
Post-chemotherapy
Value (mathematics)
- Language
- ISSN
- 1365-2168
0007-1323
Introduction Magnetic Resonance Imaging (MRI) is used to assess the response to Neoadjuvant Chemotherapy (NAC) when used in patients with breast cancer. Method This retrospective observational study compared patterns of tumour response at mid-chemotherapy and post-chemotherapy MRIs to histological outcomes. 118 cases of breast cancer, from a local database, were included. Results There was a significant association between complete pathological response in resected breast tissue and complete radiological response on both mid-chemotherapy MRI (p = 0.007) and post-chemotherapy MRI (p Conclusions Both scans have significant prognostic value. A mid-chemotherapy scan may have superior prognostic value when complete response is achieved, though larger studies are needed to determine the significance. 100% maintenance of complete radiological response after the mid-chemotherapy scan highlights the possibility that some post-chemotherapy scan could be avoided.