Background Hypoalbuminemia is frequently observed in patients with SARS‐CoV‐2 infection although its underlying mechanism and relationship with the clinical outcome still need to be clarified. Methods We retrospectively evaluated in patients with COVID‐19 hospitalised at the Fatebenefratelli‐Sacco Hospital in Milan, the prevalence of hypoalbuminemia, its association with the severity of COVID‐19, with the levels of C‐reactive protein, d‐dimer and interleukin‐6 and with clinical outcome over a follow‐up period of 30 days. Urinalysis was evaluated in a subgroup of patients. Results Serum albumin levels