Solvent- and metal-free hydroboration of alkynes under microwave irradiation
- Resource Type
- Authors
- Alexandre Arnaud; Sylvie Radix; Anne Doléans-Jordheim; Luc Rocheblave; Nadia Walchshofer; Bruna Gioia
- Source
- Tetrahedron Letters
Tetrahedron Letters, Elsevier, 2020, ⟨10.1016/j.tetlet.2020.151596⟩
- Subject
- 010405 organic chemistry
Chemistry
Pinacol
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Aryl
Organic Chemistry
[CHIM.CATA]Chemical Sciences/Catalysis
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
Coupling reaction
0104 chemical sciences
Solvent
chemistry.chemical_compound
Hydroboration
Metal free
Drug Discovery
Microwave irradiation
Metal catalyst
ComputingMilieux_MISCELLANEOUS
- Language
- English
- ISSN
- 0040-4039
Boronic esters are versatile building blocks extensively used in organic chemistry and essential to a variety of coupling reactions. In this work, the hydroboration reactions of alkynes were performed without metal catalysts using concomitant microwave irradiation that allowed a significantly reduced reaction time. Another interesting outcome of this study was that the reaction could be carried out under solvent-free conditions, highlighting the environmentally-friendly nature of our method. A wide scope of aryl- and alkylboronic acid pinacol esters were easily synthesized from the corresponding alkynes.