Heavy metal mutagenicity: insights from bioinorganic model chemistry
- Resource Type
- Authors
- Bernhard Lippert; Jens Müller; Roland K. O. Sigel
- Source
- Journal of Inorganic Biochemistry. 79:261-265
- Subject
- 10120 Department of Chemistry
Guanine
1303 Biochemistry
1604 Inorganic Chemistry
Stereochemistry
Chemistry
Hydrogen bond
Metal ions in aqueous solution
Hydrogen Bonding
Bioinorganic chemistry
DNA
Biochemistry
Tautomer
Nucleobase
Inorganic Chemistry
chemistry.chemical_compound
Deprotonation
Computational chemistry
Metals, Heavy
540 Chemistry
Nucleic Acid Conformation
Molecule
Base Pairing
Mutagens
- Language
- ISSN
- 0162-0134
The mutagenicity of metal species may be the result of a direct interaction with the target molecule DNA. Possible scenarios leading to nucleobase mispairing are discussed, and selected examples are presented. They include changes in nucleobase selectivity as a consequence of alterations in acid-base properties of nucleobase atoms and groups involved in complementary H bond formation, guanine deprotonation, and stabilization of rare nucleobase tautomers by metal ions. Oxidative nucleobase damage brought about by metal species will not be considered.