Taurine reduces hyperactive behavior in SHR rats through upregulating the proportion of CD4+CD25+Foxp3+ regulatory T cells
- Resource Type
- Authors
- Bor-Show Tzang; Jing Yi Siow; Jun-Cheng Weng; Vincent Chin-Hung Chen; Chun-Ching Chiu; Li-Jeng Chen; Tsai-Ching Hsu
- Source
- Journal of Functional Foods, Vol 56, Iss, Pp 312-320 (2019)
- Subject
- 0301 basic medicine
medicine.medical_specialty
Taurine
Medicine (miscellaneous)
Horizontal locomotion
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
Immune system
Hsp27
Internal medicine
medicine
Attention deficit hyperactivity disorder
Galectin-3
TX341-641
IL-2 receptor
cardiovascular diseases
030109 nutrition & dietetics
Nutrition and Dietetics
biology
business.industry
Nutrition. Foods and food supply
FOXP3
Attention deficit hyperactivity disorder (ADHD)
04 agricultural and veterinary sciences
medicine.disease
040401 food science
Cd4 cd25
Endocrinology
Blood pressure
chemistry
Hypertension
biology.protein
CD4+CD25+Foxp3+ regulatory T cells
business
Food Science
circulatory and respiratory physiology
- Language
- English
- ISSN
- 1756-4646
Attention deficit hyperactivity disorder (ADHD) is a most common mental illness in both children and adults. Our recent studies revealed that high-dose taurine improves hyperactivity in SHR rats by reducing mALFF signal and striatal dopamine uptake. This study further revealed the association between immune factors and hyperactivity in SHR rats fed with high-dose taurine. A positive correlation was detected between systolic blood pressure (SBP) and horizontal locomotion in SHR rats fed with high-dose taurine. Significantly higher striatal Hsp27 and galectin-3 were detected in SHR rats fed with high-dose taurine. Significantly lower IL-2 and IL-6 were detected in SHR rats fed with high-dose taurine, whereas significantly higher IL-10 was detected. Significantly increased splenic CD4+CD25+Foxp3+ regulatory T cells was detected in SHR rats fed with high-dose taurine with a negative correlation. These findings suggest that high-dose taurine reduce hyperactive behavior in SHR rats probably via multifactorial modulation on immune system.