Microfabricating high-aspect-ratio structures in polyurethane-methacrylate (PUMA) disposable microfluidic devices
- Resource Type
- Authors
- Yongxi Zhao; Robert M. Lorenz; David S. W. Lim; Gloria S. Yen; Laiying Ng; Jason S. Kuo; Daniel T. Chiu
- Source
- Lab on a Chip. 9:1951
- Subject
- Micropore Filter
Engineering
Fabrication
Microfiltration
Polyurethanes
Microfluidics
Biomedical Engineering
Breast Neoplasms
Bioengineering
Nanotechnology
Substrate (printing)
Cell Fractionation
Methacrylate
Biochemistry
Article
chemistry.chemical_compound
Cell Line, Tumor
Puma
Humans
Polyurethane
biology
business.industry
Micropore Filters
Equipment Design
General Chemistry
Microfluidic Analytical Techniques
biology.organism_classification
chemistry
Methacrylates
Female
business
- Language
- ISSN
- 1473-0189
1473-0197
We recently reported a new UV-curable polyurethane-methacrylate (PUMA) resin that has excellent qualities as a disposable microfluidic substrate for clinical diagnostic applications. This article discusses strategies to improve the production yield of PUMA chips that contain dense and high-aspect-ratio features, which presents unique challenges in demolding and bonding steps. These fabrication improvements were deployed to produce a microfiltration device that contained closely spaced and high-aspect-ratio columns, suitable for retaining and concentrating cells or beads from a highly diluted suspension.