The COVID-19 pandemic has been an unprecedented global health crisis that has threatened not only physical health, but also mental health, given its widespread impact on daily living. Individual differences in attitudes and behaviors may explain differential coping abilities in response to disruptions caused by the pandemic, and thus may shed light on risk and resilience factors for responding to current and future personal and larger-scale health crises/conditions. In particular, models of normal personality provide a useful framework for investigating differential attitudes and behaviors, which can extend to health-related attitudes and behaviors. Studies examining the Five-Factor Model (FFM) of personality, for example, have found that the personality domains are differentially associated with health-related trends such as smoking behaviors, exercise, and tendency to visit the doctor (e.g., Caspi et al., 2005). By extension, personality dimensions may further shed light on differential attitudes, health-related behaviors, and outcomes related to the COVID-19 pandemic. Some studies have noted that personality traits are associated with differential responses to COVID-19 (Asselmann et al., 2020; Lazarevic et al., 2021), but to our knowledge these associations have not been examined in daily life. The present study will examine the associations of FFM personality domains with feelings and behaviors that occur in daily life during the COVID-19 pandemic. The goals of the present study are to a) examine the associations between personality traits and self-reported attitudes, behaviors, and outcomes (i.e., likelihood of testing positive for COVID-19 or to get vaccinated) related to the COVID-19 pandemic and b) examine the extent to which these cross-sectional reports correspond with daily-life experiences.