Positive psychiatry is dedicated to the science and promotion of biopsychosocial health and resilience. Positive psychiatry has broad relevance for patients with serious mental or physical illness as well as for the general public. In this chapter, the evidence base of applied positive psychiatry for mental health promotion is reviewed. Domains of human behavior with more robust evidence to promote brain health and resilience include physical activity, social connectedness, and cognitive stimulation, proactively taking care of mental health and cultivating a balanced, optimistic outlook. Practical considerations for the integration of positive psychiatry practice are reviewed. Suggested targeted questions and measures to assess mental wellness and resilience and specific interventions shown to promote brain neuroplasticity and resilience are outlined. Early models of successful practice applications are described, with current examples of successful applications in clinical practice and in the community, including resilience-enhancing community initiatives. The Fountain of Health Initiative for Optimal Aging is highlighted as an example of applied positive psychiatry both in healthcare and in community settings.