Background: Insulin-stimulated blood flow plays a key role in glucose and insulin delivery to target tissues, such as skeletal muscle. With the development of obesity and type 2 diabetes (T2D), there are impairments in vascular insulin signaling and, consequently, blunting of insulin-induced vasodilation. However, it remains unknown if diet-induced weight loss attenuates vascular insulin resistance in both men and women with T2D. Methods: Nine women (aged 61.9±2.8 yrs; BMI 36.1±1.8) and seven men (aged 54.9±6.0 yrs; BMI 37.6±2.6) with T2D were recruited to undergo a six-month diet to induce weight loss by reducing sugar intake to This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.