Possible association between HPV16 E7 protein level and cytokeratin 19
- Resource Type
- Authors
- Alberta Lucchese; Lorenzo Lo Muzio; Gianfranco Favia; Rosario Serpico; Darja Kanduc
- Source
- Subject
- Keratinocytes
Cancer Research
viruses
Papillomavirus E7 Proteins
Uterine Cervical Neoplasms
Biology
medicine.disease_cause
Genome
Virus
Cytokeratin
Viral life cycle
Translational regulation
medicine
Humans
RNA, Messenger
Papillomaviridae
Messenger RNA
Gene Expression Profiling
Keratin-7
Zinc Fingers
Oncogene Proteins, Viral
Virology
Gene Expression Regulation, Neoplastic
Oncology
Cancer research
Carcinoma, Squamous Cell
Keratins
Female
Viral disease
Carcinogenesis
Transcription Factors
- Language
- English
The mechanisms employed by human papillomaviruses (HPVs) to control the replication of the viral genome and the expression of the viral genes are extremely complex and further complicated by the fact that the viral life cycle is intricately tied to the differentiation program of its host epithelial tissue. Indeed, HPV-induced immortalization of keratinocytes and disruption of the normal cytokeratin (CK) expression pattern progress pari passu during the stepwise process that preludes to squamous cell carcinoma. In our study, we have analyzed the interaction occurring between HPV type 16 E7 mRNA and the intermediate cytokeratin filaments 7 and 19 and report data in favor of a possible association between HPV16 E7 protein level and CK19. © 2004 Wiley-Liss, Inc.