Actinic cheilitis is a potentially malignant inflammatory labial pathology. It usually affects the lower lip in white patients between 40 and 80 years of age, with a history of long and continuous sun exposure, as seen in the reported cases. In this work, the classification proposed by Silva et al. (2006) was used to classify the lesions as mild (first case), moderate (second case), or severe (third case). It is important to emphasize the importance of clinical diagnosis, since it allows prevention and treatment, before a possible progression to carcinoma. The treatment of first choice in all cases was the topical use of a compounding preparation (50% aloe vera gel and 5% calendula) with the aim of acting as a moisturizer, an emollient, and an anti-inflammatory agent, thereby increasing vascularization and oxygenation, as well as initiating the repair of collagen and healing of the lesions.