Simultaneous cyclization and derivatization of peptides using cyclopentenediones
- Resource Type
- Authors
- Omar Brun; Anna Grandas; Lewis J. Archibald; Jordi Agramunt; Enrique Pedroso
- Source
- Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
- Subject
- 010402 general chemistry
01 natural sciences
Biochemistry
Catalysis
chemistry.chemical_compound
Residue (chemistry)
Cisteïna
Moiety
Organic chemistry
Cysteine
Physical and Theoretical Chemistry
Derivatization
chemistry.chemical_classification
Molecular Structure
010405 organic chemistry
Organic Chemistry
Estructura molecular
food and beverages
Cyclic peptide
0104 chemical sciences
chemistry
Cyclization
Pèptids
Peptides
Molecular structure
Conjugate
- Language
- ISSN
- 1523-7060
Unprotected linear peptides containing N-terminal cysteines and another cysteine residue can be simultaneously cyclized and derivatized using 2,2-disubstituted cyclopentenediones. High yields of cyclic peptide conjugates may be obtained in short reaction times using only a slight excess of the cyclopentenedione moiety under TEMPO catalysis and in the presence of LiCl.