A first and general route to naphthylisoquinoline alkaloids: the total synthesis of O-methyl-tetradehydro-triphyophylline
- Resource Type
- Authors
- Johannes R. Jansen; Gerhard Bringmann
- Source
- Tetrahedron Letters. 25:2537-2540
- Subject
- Chemical coupling
Intramolecular reaction
Bicyclic molecule
Chemistry
Stereochemistry
Alkaloid
Organic Chemistry
Drug Discovery
Regioselectivity
Total synthesis
Biochemistry
- Language
- ISSN
- 0040-4039
The first total synthesis of a naphthylisoquinoline alkaloid is described. The required ortho selective mixed coupling of the alkaloid moieties 2 and 6 is achieved intra-molecularly by the assistance of a reversibly thrown benzylether type auxiliary bridge.