Introduction: Primary endocrine therapy (PET) is used in breast cancer, for patients deemed unsuitable for surgery due to co-morbidities or frailty. A review of the first 12 months of a nurse-led primary endocrine clinic was performed to determine whether the clinic was effective and whether referrals and patient selection was appropriate. To determine frailty, the Vulnerable Elders score (VES-13), a short frailty-screening tool, was used for new referrals. Methods: Patients currently on PET were identified from a prospectively collected database, including those who began treatment prior to the initiation of the clinic and VES-13 scoring. Demographics and treatment information including duration, therapeutic agent, changes in treatment, VES-13 score and discharge to GP, was determined from patient records. Missing information was sought from the patient’s GP. Results: 128 patients were identified; 49 patients previously on PETand 79 new patients. Average age was 83 and 82 years respectively. 62.0% had a VES-13 score recorded. 91.8%were deemed frail (VES-13>3). 94.0%were on aromatase inhibitors with an average treatment duration of 2.4 years. 15.7% had treatment agent changed and 10.1%were referred for other treatment. Mortality was 11.8%. 11.0% were discharged to the GP. Conclusion: These results demonstrate that a nurse-led clinic for PET is effective and patients were appropriately selected. It highlighted the difficulty of implementing a screening tool as well as areas for improvement. Development of the service includes involvement of geriatric services with cognitive assessment as well as the safe discharge of patients on PET to the community.