Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers
- Resource Type
- Source
- Bioorganic & Medicinal Chemistry Letters. 22:7207-7213
- Subject
Macrocyclic Compounds Genotype Stereochemistry medicine.medical_treatment Clinical Biochemistry Mutant Pharmaceutical Science Hepacivirus Viral Nonstructural Proteins Ring (chemistry) Biochemistry Structure-Activity Relationship Genotype 1b Catalytic Domain Drug Discovery medicine Animals Potency Protease Inhibitors Molecular Biology Binding Sites Protease Chemistry Organic Chemistry Intracellular Signaling Peptides and Proteins Rats Molecular Docking Simulation Kinetics Liver Cyclization Rat liver Mutation Molecular Medicine Carrier Proteins Linker Half-Life - Language
- ISSN
- 0960-894X